Prof. Raphael Mechoulam

Hebrew University, Medical faculty, Institute for Drug Research

Ein Kerem, Jerusalem, 9112001, Israel

Type of Practice:

Education Associations



RM was born in Sofia, Bulgaria in 1930. His father was a physician and head of the Jewish
hospital in Sofia. RM went to an American Grade School in Sofia for 4 years until it was
closed by the pro-German government.
From 1942, for over 2 years – during the 2nd world war – his family lived in small villages in the Balkans. His parents believed that the family is safer there. Nevertheless his father was taken to a concentration camp for part of this time.
RM immigrated to Israel in 1949. He studied biochemistry at the Hebrew University in
Jerusalem (M.Sc.) and the Weizmann Institute in Rehovot (Ph.D.) He spent a year in New
York, at the Rockefeller Institute and returned to the Weizmann Institute in 1960. He worked on the chemistry of various natural products. He initiated his work on hashish, which he received from the Police. In 1966 he moved to the Hebrew University, where he became a full professor in 1972. From 1979 to 1982 he was Rector (Academic Head) of the Hebrew University. He retired in 2000 but continued his research. He still has a lab with 3-4 post-doctoral researchers.
His work has been mostly on the chemistry of natural products, the best known being on
cannabinoids. In collaboration with numerous colleagues in Israel and abroad he has also
published in pharmacology and on clinical trials.
He has published about 470 scientific papers and has received numerous national and
international prizes, including the Israel Prize – the most prestigious Israeli Prize – as well as an prize from the US National Institutes of Health. He is a member of the Israel Academy of Sciences, where he headed the Natural Sciences section from 2007 to 2013.
He married Dalia (born Borovitch) in 1955 and they have 3 children, Roy, a professor of
mathematics at the Technion in Haifa, Hadas, an M.D. ophtalmologist and Dafna, an M.D.
pediatric neurologist. He has 7 grandchildren.


R. Mechoulam and Y. Shvo. The structure of cannabidiol. Tetrahedron, 19,
2073-2078 (1963).

Y. Gaoni and R. Mechoulam. The structure and synthesis of cannabigerol, a new
hashish constituent. Proc. Chem. Soc., 82 (1964).

Y. Gaoni and R. Mechoulam. Isolation, structure and partial synthesis of an
active constituent of hashish. J. Amer. Chem. Soc., 86, 1646-1647 (1964).

W.A. Devane, L. Hanus, A. Breuer, R.G. Pertwee, L.A. Stevenson, G. Griffin,
D. Gibson, A. Mandelbaum, A. Etinger and R. Mechoulam. Isolation and
structure of a brain constituent that binds to the cannabinoid receptor. Science
258, 1946-1949 (1992).

R. Mechoulam et al. Identification of an endogenous 2-monoglyceride, present
in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50, 83-
90 (1995).

D. Panikashvili, C. Simeonidou, S. Ben-Shabat, L. Hanus, A. Breuer, R.
Mechoulam and E. Shohami. An endogenous cannabinoid (2-AG) is
neuroprotective after brain injury. Nature 413, 527-531 (2001).

R. Smoum, A. Bar, B. Tan, G. Milman, M. Attar-Namdar, O. Ofek, J.M. Stuart, A.
Bajayo, Y. Tam, V. Kram, D. O’Dell, M. J. Walker, H. B. Bradshaw, I. Bab, R.
Mechoulam. Oleoyl serine, an endogenous regulator of skeletal mass. Proc Natl Acad
Sci U S A. 107, 17710-5 (2010).

M. Feldman, R. Smoum, R. Mechoulam, D. Steinberg. Potential combinations of
endocannabinoid/endocannabinoid-like compounds and antibiotics against
methicillin-resistant Staphylococcus aureus. PLoS One. e0231583 (2020).

G.N. Petrie, K.I. Wills, F. Piscitelli, R. Smoum, C.L.Limebeer, E.M.Rock,
S.M.Ayoub, A.E.Humphrey, M.Shepard-Perkins, A.H.Lichtman, R. Mechoulam,
L.H.Parker. Oleoyl Glycine: Interference with the aversive effects of acute naloxone-
precipitated MWD, but not morphine reward, in male Sprague-Dawley rats.
Psychopharmacology (Berl). 236, 2623-2633 (2019).