This page contains research and articles pertaining to cannabis and mental health. Cannabis, especially CBD, has been investigated with some promise to treat various mental health conditions, such as social anxiety disorder and PTSD. It is important to screen for mental health conditions, especially risk of psychosis, when considering use of cannabis. Cannabis Use Disorder information is also provided.

Brief Report

Factors Associated with Problematic Cannabis Use in a Sample of Medical Cannabis Dispensary Users

Lo LA, MacCallum CA, Yau J, Panenka W, Barr A. Psychiatry and Clinical Psychopharmacology. 2022

Research Article
Differences in those who prefer smoking cannabis to other consumption forms for mental health: what can be learned to promote safer methods of consumption?Cannabinoids and Mental Health Risks

Lo LA, MacCallum CA, Yau J, Barr A.  Journal of Addictive Diseases. 2022

Chapter 33
Cannabinoids and Mental Health Risks

Narouze SN, MacCallum CA. eds. Cannabinoids and Pain. Springer; 2021

Chapter 38
Cannabis Use Disorder

Narouze SN, MacCallum CA. eds. Cannabinoids and Pain. Springer; 2021

Research Article
Characterization of mental health in cannabis dispensary users, using structured clinical interviews and standardized assessment instruments
BMC Psychiatry. 2019; 19

Yao JC… MacCallum CA, et al.

Genetic predisposition vs individual-specific processes in the association between psychotic-like experiences and cannabis use. JAMA Psychiatry. 2019; 76(1)

Association of cannabis with long-term clinical symptoms in anxiety and mood disorders: a systematic review of prospective studies. The Journal of Clinical Psychiatry. 2018; 79(4)

Medical cannabis and mental health: a guided systematic review. Clinical Psychology Review. 2017; 51

Prevalence and correlates of DSM-5 cannabis use disorder, 2012-2013: findings from the National Epidemiologic Survey on Alcohol and Related Conditions–III. American Journal of Psychiatry. 2016; 173(6)

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translational Psychiatry. 2012; 2(3)

Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. Biological Psychiatry. 2005; 57(6)

Individuals seeking treatment for cannabis-related problems in Ontario: demographic and treatment profile. European Addiction Research. 2005; 11(3)